��������

YOU ARE THE WORDS, I AM THE NETU PLAY ME. �� �� JESSICA: JEFF AND CINDY GOLDBERG HAVE BEEN IN PERFECT HARMONY FOR MORE THAN FIVE DECADES. YOU GUYS FINISH EACH OTHER'S SENTENCES, YOU KNOW, DO WE? BUT, ABOUT FIVE YEARS AGO CINDY STARTED NOTICING CNGHAES IN JEFF. >> HE WASN'T ABLE TO DO THE CHECKBOOK ANYME.OR HE WAS GETTING CONFUSED ABOUT THINGS JESSICA: AFTER TALKING WITH THEIR KIDS, THEY DECIDED TO SEE A DOCTOR, AND THEY GOT A HEARTBREAKING DIAGNOSIS. >> THE NEULOROGIST SAID, YOU KNOW, IT LOOKS LIKE IT COULD BE ALZHEIMER'S. SO THEN HE HAD THE BRAIN SCAN DONE AND THEY SAW THE AQPL JESSICA: THAT'S WHEN THEY HEARD ABOUT A BREAKTHROUGH TREATMENT JUST GOING INTO TRIALS AT BRIGHAM AND WOMEN'S HOSPITAL. A NASAL SPRAY VACCINE, DESIGNED TO STOP THE PROGRESSION OF ALZHEIMER'S DISEE.AS >> I JUST SAID, YEAH, I'LL DO IT. I HAVE NOTHING TO LOSE EXCEPT EVERYTHING TO GAIN. >> WHAT WE'RE DOING, IT'S NEVER BEEN DONE BEREFO JESSICA: DR. HOWARD WEINER IS THE CO-DIRECTOR OF THE ANN ROMNEY CENTER AT THE BRIGHAM. HE'S WORKING ON THIS GROUNDBREAKING APPROACH TO ALZHEIMER'S TREATMENT FOR THE PAST TWENTY YES.AR >> THE HARDEST THING FOR A DOCTORS TO SIT WITH A PATIENT OR THREI FAMILY WHO'S ILL AND TO SAY TO THEM, WE DON'T HAVE ANY TREATMENT. JESSICA: THE CONCEPT IS DECEPTIVELY SIMPLE, THE NASAL SPRAY TRAINS THE PATIENT'S OWN BODY TO FIGHT BACK. IT RELSIE ON AN IMMUNE MODULATOR CALLED PROTOLLIN, A DRUG ME UPAD OF PROTEINS DERIVED FROM BACTERIA, WHICH ACTIVATE WTEHI BLOOD CESLL TO START CLEARING THE PLAQUE BUILD-UP ON THE BRAIN, A HALLMARK OF THIS DISEASE. >> WHAT WE'RE DOING IS TRIGGERING THE BODY'S OWN IMMUNE SYSTEM, THE BODY'S OWN DEFEESNS TO KIND OF CURE ITSE.LF JESSICA: THE VACCINE IS CURRENTLY IN PHASE ONE TRIALS, AN EARLYTA SGE WITH JUST 16 PARTICIPANTS. RESEARCHERS WILL MONITOR THAT GROUP FOR SIX MONTHS, TESTING DOSAGE AND SAFETY, BEFORE HOPEFULLY LAUNCHING A SECOND, LARGER TRI.AL >> WE'RE MAKING GOOD PROGRESS SO R.FA IT SEEMS TO BE GOING WELL, AND WE'RE NOT SEEING ANY MAJOR ISSU.ES JESSICA:R. D TANUJACHITNIS IS THE PRINCIPALNV IESTIGATOR FOR THE TRIAL, PART OF HER ROLE IS TO RECRUIT PATIENTS TO TAKE PA.RT THOUGH SHE SAYS PERSUADING PEOPLE HASTN' BEEN A CHALLENGE. >> WE WERE REALLY VERY PLEASED AND SOMEWHAT OVERWHELMED BY THE AMOUNT OINF TEREST THAT THERE WAS IN THIS VACCINE THINK IT'S BECAUSE SO MANY PEOPLE ARE AFFECTED BY ALZHEIMER'S DISEASE, FAMILY MEMBERS, LOVED ONES,ND T AHE FACT THAT THERE HASN'T BEEN MANY THERAPIES AVAILAE.BL JESSICA: FOR DR. WEINER THIS MISSION IS PERSONAL. >> I LOST MY MOTHER TO ALZHEIMER'S HEARING WHAT ALL THE PEOPLE HAVE GONE THROUGH WHEN THEIR FAMILY MEMBERS HAVEN'T AND, YOU KNOW, GOING THROUGH IT MYSELF WITH MY MOTHER. SO, I MEAN, YOU'RE NOT GOING TO QUIT. JESSICA: AND THAT FIGHTING SPIRIT IS STRONG IN THE GOLDBERGS, TOO, EVEN DOWN THE YOUNGEST MEMBERSF O THIS FAMILY. >> ONE OF MY GRANDSONS HE'S EIGHT. HE GOES GM.RA YOU KNOW, I WANT TO BE A DOCTOR WHEN I GROW UP. I WANT TO FIND AUR CE